- J. Srinivasa Rao
- K. Suresh Kumar
- P. Jayachandra Reddy
- J. Naga Mallika
- M. Sri Madhu Sri
- M. Prasada Rao
- C. Gopinath
- Ravi Kumar vejendla
- G. Hemanth Kumar
- J. Srinivasarao
- Nalla Priyanka
- P. Brahmeswari
- M. Sowjanya
- M. Ramayyappa
- Ayanam Vasavi
- Miriyala Mrunalini
- Ayanam Vasanthi
- H.S.P. Syloosha
- V. Alekya Satyasri
- G. premi
- Ch. Prudhvi
- Ayinam Vasavi
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Raveendra Babu, G.
- Stability Indicating Liquid Chromatographic Method for Aripiprazole
Authors
1 Dr.Reddy’s Laboratories Ltd, Bachupally, Hyderabad, Andhra Pradesh, IN
2 United States Pharmacopeia-India Pvt. Ltd, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad, IN
3 KrishnaTeja Pharmacy College, Tirupathi, Chittor (Dt), Andhra Pradesh, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 1, No 1 (2011), Pagination: 3-7Abstract
A novel stability indicating liquid chromatographic assay method was developed and validated as per ICH guide lines for the quantitative estimation of Aripiprazole in tablet formulation. An isocratic reverse phase LC-method was developed using Phenomenex Luna C18, 150 x 4.6mm, 5μm column and a mobile phase comprising of Acetonitrile and Phosphate buffer, 0.05M (40:60 v/v). The detector set at 227nm with flow rate of 1.0mL min-1. The method is Linear in rage of 25μg mL-1 to 200 μg mL-1. The Accuracy of the method was found to be in the range of 99.95% to 100.0%. The mean Inter and Intraday assay Relative Standard deviation (%RSD) were less than 1.0%. The Analyte and mobile phase were stable up to 48hours. The Proposed method was found to be Linear, precise and accurate for the quantitative estimation of Aripiprazole in tablet formulations and can be used for commercial purposes.Keywords
Aripiprazole, Liquid Chromatography, Stress Degradation and Method Validation.- Comparative In Vitro Dissolution Assessment of Three Different Brands of Lansoprazole Capsules
Authors
1 Hindu College of Pharmacy, Amravati Road, Guntur, Andhrapradesh, IN
2 MAM College of Pharmacy, Narasaraopet, Guntur (Dt), Andhrapradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 2 (2011), Pagination: 57-65Abstract
The present study has made an attempt to compare % release of three different brands (Lanzol, Lanzap and Lan) of lansoprazole using USP Type II (Paddle) dissolution Apparatus in three Media (phosphate buffer pH 6.0, 6.8 and 7.4). It has been observed from the dissolution profile that more than 90% of Lansoprazole is released from each capsule at 30.0 minutes time point. The F1 and F2 values of Lanzol Vs Lanzap are 7.02% and 59.87%, Lanzol Vs Lan are 1.51% and 81.99% and Lan Vs Lanzop are 0.38% and 59.98% at pH6.0; The F1 and F2 values of Lanzol Vs Lanzap are 7.65% and 55.95%, Lanzol Vs Lan are 3.91% and 69.18%, Lan Vs Lanzop are 3.90% and 61.99% at pH 6.8.The F1 and F2 values of Lanzol Vs Lanzap are 4.12% and 67.10%, Lanzol Vs Lan 2.46%, 72.60%, Lan Vs Lanzop 1.70% and 84.53% at pH 7.4. In all three Media % Release pattern is similar; However in pH 7.4 media % Release is about 100% at 45minutes.Keywords
Lansoprazole, Dissolution, UV Method.- New Comprehensive HPLC assay Method for Donepezil Hydrochloride
Authors
1 Sri Indu Institute of Pharmacy, Sheriguda (Village), Ibrahimpatan-501 510, RR Dist., Andhra Pradesh, IN
2 Dr.Reddy’s Laboratories Ltd, Bachupally, Hyderabad, Andhra Pradesh, IN
3 United States Pharmacopeia-India Private Limited, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 10 (2011), Pagination: 1508-1512Abstract
A novel stability indicating liquid chromatographic assay method was developed and validated as per ICH guidelines for the quantitative estimation of Donepezil in tablet formulation. An isocratic reverse phase LC-method was developed using Zorbax SB C18, 150 x 4.6mm, 5μm column and a mobile phase comprising of a mixture of water: acetonitrile (68:32), pH adjusted to 4.5 with trifluoro acetic acid. The detector set at 229nm with flow rate of 1.0mL min-1. The method is linear between 5 μg mL-1 to 25 μg mL-1 and the limit of detection (LOD) is 0.5 μg mL-1. The Accuracy of the method was found to be in the range of 99.70% to 100.26%. The mean Inter and Intraday assay Relative Standard deviation (%RSD) were less than 0.69%. The Proposed method was found to be Linear, precise and accurate for the quantitative estimation of Donepezil in tablet formulations and can be used for commercial purposes.Keywords
Donepezil, Liquid Chromatography, Stress Degradation and Method Validation.- Evaluation of Anti-bacterial and Anti-inflammatory Activities of Ethanolic Extract of Hibiscus hirtus Linn. Leaves
Authors
1 Department of Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, Andhra Pradesh, IN
2 Dept. of Pharmacology, Brilliant Group of Institutions, Abdullapaur, R.R. Dist., Hyderabad, Telangana, IN
3 Department of Analysis, A.K.R.G. College of Pharmacy, Nallajerla, Andhra Pradesh, IN
4 Vijaya Teja Degree College, Addanki, Andhra Pradesh, IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 5 - 10Abstract
The current investigation is started to find the antibacterial and anti-inflammatory activities of the sub shrub Hibiscus hirtus L. The leaves of this conventional shrub were found to possess' different activities which incorporate antibacterial and hostile to helminthic effects. Thus we made an endeavor to perform extraction utilizing ethanol as solvent and soxhlation as a strategy for extraction. The leaves were priorly researched for their pharmacognostic, phytochemical and physical parameters. The antibacterial action of the ethanolic leaf extract was conveyed at various concentrations on strains of gram positive and gram-negative bacteria, for example, Staphylococcus aureus and Escherechia coli individually by utilizing cup and plate technique. The outcomes were outfitted as the zone of inbition acquired around every grouping of the concentrate and were compared with those of standard antibiotic utilized in the analysis, amoxycillin. Anti-inflammatory activity of Hibiscus hirtus L was studied and compared with standard drug, ibuprofen. Ethanollic concentrate of leaves (2.5- 15 mg/ml) and ibuprofen (2.5-15 mg/ml) were utilized to measure the paw edema by plethysmometer and compared with control groups. Hibiscus hirtus L showed critical decrease of paw edema in the chosen model of inflammation for example formalin prompted chronic model of inflammation. Ethanollic concentrate of the plant leaves showed anti- microbial and anti-inflammatory impacts.
Keywords
Hibiscus hirtus L, Anti-inflammatory, Antimicrobial activity, ExtractionReferences
- Ahameethunisa A.R., Hopper W. Antibacterial activity of Artemisia nilagirica leaf extracts against clinical and phytopathogenic bacteria BMC Comple. Alt. Med. 2010; 10:6.
- Al Farug A., Ibrahim M., Mahmood A., Chowdhury M., Rashid R.B., Kuddus R., Rashid M.A. Pharmacological and phytochemical screenings of ethanol extract of Leeamacrophylla Roxb. Innov. Pharm Pharmacother. 2014;2: 321–327.
- Anosike C.A., Obidoa O., Ezeanyika L.U. Membrane stabilization as a mechanism of the anti-inflammatory activity of methanol extract of garden egg (Solanum aethiopicum) DARU J. Pharmaceut. Sci. 2012; 20(1): 76.
- Arokiyaraj S., Sripriya N., Bhagya R., Radhika B., Prameela L. Phytochemical screening, antibacterial and free radical scavenging effects of Artemisa nilagirica. Mimosa pudica and Clerodendrum siphonanthus – An in vitro study. Asian Pacific J. Tropic. Biomed. 2012;29: S601–S604.
- Avula B., Wang Y.H., Smillie T.J., Mabusela W., Vincent L., Weitz F., Khan I.A. Quantitative determination of flavonoids by column high-performance liquid chromatography with mass spectrometry and ultraviolet absorption detection in Artemisia afar and comparative studies with various species of Artemisia plants. J. AOAC Int. 2009;92: 633–644.
- Banerji A., Luthriya D.L., Kokate S.D. Toxicity of capillin, the insecticidal principle of Artemisia nilagirica Clarke. Indian J. Exp. Biol. 1990;28: 588–589.
- Blaszyle M., Holley R.A. Interaction of monolaurin, eugenol and sodium citrate on growth of common meat spoilage and pathogenic organisms. Int. J. Food Microbial. 1998;39: 175–183.
- Nathan C. Points of control in inflammation. Nature. 2002;420:846-52. 9. Gouwy M, Struyf S, Proost P, Van Damme J. Synergy in cytokine and chemokine network amplifies the inflammatory response. Cytokine Growth Factor Rev. 2005;16: 561-80.
- Wellen KE, Hotamisligil GS. Inflammation, stress and diabetes. J. Clin. Invest. 2005;115: 1111-9.
- Hanauer SB. Inflammatory bowel disease: epidemiology, pathogenesis and therapeutic opportunities. Inflamm. Bowel Dis. 2006; 12:3-9.
- Whicher J, Chambers R. Mechanisms in chronic inflammation. Immunol. Today. 1984;5: 3-4.
- Vinay K, Abdul KA, Nelson F, Aster JC. Robbins and Cotran’s Pathologic basis of diseases. 8th ed Philadelphia: Elsevier Publishers; 2010: 43-77.
- Laurence LB , Bruce AC, Bjorn CK. Goodman and Gilman's The pharmacological basis of therapeutics.12th ed China: McGraw-Hill Publishers; 2011.
- Eisenberg DM, Kessler RC and Foster C. 1993. Unconventional Medicine in the United States: Prevalence, Costs and Patterns of Use. N Eng J Med. 328:246-52.
- Rakh MS and Chaudhari SR. Evaluation of CNS depressant activity of Momordicadioica Roxb wild fruit pulp. Int. J. Pharm. Pharm. Sci. 2010;2(4):124-6.
- Perry JM. Medicinal plants of East and Southeast Asia: attributed properties and Uses. MIT Press, Cambridge, MA. 1980;334-60. 18. Mahadevan N, Shivali and Kamboj P, Hibiscus sabdariffa L.-An Overview. Natural Product Radiance. 2009;8(1):77-83.
- Alviano DS, Alviano CS. Plant extracts: search for new alternatives to treat microbial diseases. Curr Pharm Biotechnol, Jan, 2009; 10(1): 106–121.
- Malini M, Abirami G, Hemalatha V, Annadurai G. Antimicrobial activity of ethanolic and aqueous ex-tracts of medicinal plants against waste water pathogens. Int J Res Pure Appl Microbiol. 2013; 3(2): 40–42.
- Zhang R, Eggleston K, Rotimi V, Zeckhauser RJ. Antibiotic resistance as a global threat: evidence from China, Kuwait and the United States. Global Health, Apr 7, 2006; 2: 6.
- Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. 2000; 88(2): 308–316.
- Talib WH, Mahasneh AM. Antimicrobial, cytotoxicity and phytochemical screening of Jordanian plants used in traditional medicine. Molecules. 2010; 15(3): 1811–1824.
- Cruz MC, Santos PO, Barbosa Jr AM, de Melo DL, Alviano CS, Antoniolli AR, Alviano DS, Trindade RC. Antifungal activity of Brazilian medicinal plants involved in popular treatment of mycoses. J Ethnopharmacol. 2007; 111(2): 409–412.
- Antimicrobial activity of ethanolic extracts from some medicinal plants. Australian Journal of Basic and Applied Sciences. 2011; 5(11): 678-683.
- Evaluation of antimicrobial activity of various medicinal plants extracts of Latur zone against pathogens. International Journal of Life Sciences and Resource. 2016; 2(5): 612-618.
- Antimicrobial activity of ethanolic extracts from some medicinal plants. Australian Journal of Basic and Applied Sciences. 2011; 5(11): 678-683.
- M. Hemalatha, B. Arirudran, A. Thenmozhi, U.S. Mahadeva Rao. Antimicrobial Effect of Separate Extract of Acetone, Ethyl Acetate, Methanol and Aqueous from Leaf of Milkweed (Calotropis gigantea L.). Asian J. Pharm. Res. 2011; 1(4): 102- 107.
- Preeti Tiwari. Antimicrobial Activity of Amritarishta Prepared by Traditional and Modern Methods. Asian J. Pharm. Res. 2014; 4(2): 114-116.
- A. Sureka, C. Mary Sharmila, R. Chithra Devi, N. J. Muthu Kumar, V. Banumathi. Evaluation of In Vitro Anti-Inflammatory activity of Kusta Gaja Kesari - A Siddha Herbo Mineral Formulation against Albumin Protein Denaturation. Asian J. Pharm. Res. 2018; 8(3): 145-147.
- Keerti Shrivastava, Sherendra Sahu, Skand K. Mishra, Kantishree De. In vitro Antimicrobial Activity and Phytochemical Screening of Syzygium aromaticum. Asian J. Res. Pharm. Sci. 2014; 4(1): 12-15.
- Preeti Tiwari. Antimicrobial Activity of Ashwagandharishta Prepared by Traditional and Modern Methods. Asian J. Res. Pharm. Sci. 201; 4(3): 115-117.
- Nidhi Rao, Sandhya Mittal, Sudhanshu, Ekta Menghani. Assessment of Phytochemical Screening, Antioxidant and Antibacterial Potential of the Methanolic Extract of Ricinus communis L. Asian J. Pharm. Tech. 2013; 3(1): 20-25.
- Punasiya Rakesh, Pillai Sujit, Yadav Janeshwer. Isolation and identification of compounds from the leaves extract of Hibiscus syriacus L. Asian J. Pharm. Tech. 2015; 5(1): 8-12.
- Merlin NJ, Parthasarathy V, Manavalan R, Devi P, Meera R. Phyto-Physico chemical evaluation, Anti-Inflammatory and Anti microbial activities of Aerial parts of Gmelina asiatica. Asian J. Research Chem. 2009; 2(1): 76-82.
- Swapnali Mohite, Rutuja Shah, Naziya Patel. Antimicrobial Activity of Leaves extracts of Cassia tora. Res. J. Pharma. Dosage Forms and Tech. 2018; 10(1): 10-12.
- R. Suresh, D. Benito Johnson, Appalaraju Gorle, Ashok Kumar Javvadi, Tamil Selvan A. The Wound healing, anti inflammatory and haemostatic effect of Eupatorium odoratum. Research J. Pharmacognosy and Phytochemistry. 2012; 4(2): 75-79..
- Formulation and Evaluation of Sustained Release Stavudine Microspheres by Ionotropic Gelation Method
Authors
1 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Chemistry, Vijaya Teja Degree College, Addanki - 523201, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 2 (2022), Pagination: 119-124Abstract
As a novel drug delivery system, microspheres improve the efficacy of a drug, increase the time of action, lower the number of times in which a dosage form needs to be administered, and to increase patient compliance. Oral administration side effects such as gastric irritation are lessened through the use of microspheres. Ionotropic gelation was used to create HPMC K15M, Guar gum, and Carbopol 934 microspheres with different concentrations of Carbopol 934 polymer. Cross-linking was accomplished with the use of calcium chloride. In order to conduct a systematic evaluation of all the preparations, we performed various tests: morphology, FTIR, DSC, entrapment efficiency, size, microsphere size, and in-vitro drug release. The discrete, free-flowing, and spherical particles of prepared Stavudine microspheres were found. In compliance with standards, the mean particle size was in the range of 72.64 to 95.22 percent. In vitro drug release studies were performed in phosphate buffer solution with a pH of 6.8. As the concentration of sodium alginate and calcium chloride increased, the percentage of drug release was reduced. In the case of F9 formulation, which contained Stavudine, the decreased drug release rate was obtained via carbopol 934(1:3), sodium alginate, and calcium chloride. Conclusively, the present study shows that Stavudine microsphere preparation and formulation F9 are successful. Stavudine microspheres must be prepared in order to preserve an effective drug concentration in serum for a long time, while reducing gastrointestinal irritation.Keywords
Microspheres, Controlled Release, Stavudine, In-vitro StudiesReferences
- Nikam V, Gudoorkar V, Microspheres- A novel drug delivery system:an overview. Int J Pharma Chem Sci. 2012; 1(1):113-128.
- Kristmundsdottir T, Ingvarsdottir K. Ibuprofen microcapsules: the effect of production variables on microcapsule properties. Drug Development and Industrial Pharmacy. 1994;20(5):769–778.
- Capan Y, Jiang G, Giovagnoli S, Na K-H, DeLuca PP. Preparation and characterization of poly(D,L-lactide-co-glycolide) microspheres for controlled release of human growth hormone. AAPS PharmSciTech. 2003;4(2)
- Gohel MC, Amin AF. Formulation optimization of controlled release diclofenac sodium microspheres using factorial design. Journal of Controlled Release. 1998;51(2-3):115–122.
- Woo BH, Jiang G, Jo YW, DeLuca PP. Preparation and characterization of a composite PLGA and poly(acryloyl hydroxyethyl starch) microsphere system for protein delivery. Pharmaceutical Research. 2001;18(11):1600–1606.
- Davis SS, Illum L. Polymeric microspheres as drug carriers. Biomaterials. 1988;9(1):111–115.
- Ritschel WA. Biopharmaceutic and pharmacokinetic aspects in the design of controlled release peroral drug delivery systems. Drug Development and Industrial Pharmacy. 1989;15:1073–1103.
- Tripathi KD. Essentials of Medical Pharmacology. New Delhi, India: Jaypee Brothers’ Medical Publishers (P) Ltd; 2007.
- Martin AR. Antiviral Agents; Text Book of Organic Chemistry and Pharmaceutical Chemistry. New York, NY, USA: Lippincot-Reven; 1998.
- Lewis GA, Mathieu D, Phan-Tan-Luu R. Pharmaceutical Experimental Design. New York, NY, USA: Marcel Dekker; 1961.
- Singh B, Ahuja N. Book Review on Pharmaceutical experimental Design. 1999.
- Nelson KG, Wang LY. Determination of time course of tablet disintegration II: method using continuous functions. Journal of Pharmaceutical Sciences. 1978;67(1):86–89
- Singh B, Dahiya M, Saharan V, Ahuja N. Optimizing drug delivery systems using systematic ‘design of experiments.’ Part II: retrospect and prospects. Critical Reviews in Therapeutic Drug Carrier Systems. 2005;22(3):215–293.
- Singh B, Mehta G, Kumar R, Bhatia A, Ahuja N, Katare OP. Design, development and optimization of nimesulide-loaded liposomal systems for topical application. Current Drug Delivery. 2005;2(2):143–153.
- Aberturas MR, Molpeceres J, Guzmán M, García F. Development of a new cyclosporine formulation based on poly(caprolactone) microspheres. Journal of Microencapsulation. 2002;19(1):61–72.
- Kim CK, Kim MJ, Oh KH. Preparation and evaluation of sustained release microspheres of terbutaline sulfate. International Journal of Pharmaceutics. 1994;106(3):213–219.
- Design, Formulation and Evaluation of Fexofenadine HCl Immediate Release Tablets by Solid Dispersion Method using Solvent Evaporation Technique
Authors
1 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Chemistry, Vijaya Teja Degree College, Addanki, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 4 (2022), Pagination: 290-298Abstract
Currently, this study focuses on developing immediate-release Fexofenadine hydrochloride tablets. The Fexofenadine HCl tablets have super disintegrants that help to accelerate dissolution and bioavailability. Sodium lauryl sulphate, microcrystalline cellulose as filler, crospovidone, and sodium starch glycolate were used to make the tablets using a direct compression method (2-8 percent). Pre and post compressional parameters were used in the preparation of the tablets. The In-vitro disintegration study shows that as concentration of sodium starch glycolate is increased, there is an increase in the amount of time it takes for the solution to disintegrate, but at the same time, there is a decrease in the amount of time it takes for the solution to disintegrate when the crospovidone level is increased. When combined with the crospovidone tablet formulation, the test found that the resulting tablets broke down in approximately 3 to 6 minutes, with enough force to release the fragments but not to harm the friability of the product. It was found that Fexofenadine hydrochloride tablet, a fast-acting form of treatment for allergic rhinitis, could be formulated in an immediate-release form.Keywords
Allergic Rhinitis, Crospovidone, Croscarmellose SodiumReferences
- M.L.R. Medina, V. Kumar. Evaluation of cellulose II powders as a potential multifunctional excipient in tablet formulations, International Journal of Pharmaceutics 322, pp: 31-35 (2006).
- M.C. Gohel, Improving the Tablet Characteristics and Dissolution Profile of Ibuprofen by using a Novel Co processed Superdisintegrant, AAPS, Pharm SciTech, vol. 8, no.1, Article 13: E1-E6 (2007).
- European Pharmacopoeia Supplement, Strasbourg, France: Council of Europe. 2002
- A. Goran. Tablets and compaction, in Aulton, M. E., Pharmaceutics, The Science of Dosage Form Design, 2nd Edition, Churchill Livingstone, New York, , pp. 397-440. 2002
- A. John, M. Chris. Modified-release peroral dosage forms, in: Aulton, M.E., Pharmaceutics, The science of dosage form design, 2nd Edition, Churchill Livingstone, New York, pp. 289-305. 2002
- Azeem S, Sharma S. Immediate drug delivery systems: review, Int. J. Biopharm. Toxicol., vol. 1, no. 1, pp 24-46, 2011
- Leah E, Appel DT, Friesen JE, Byers MD, Crew BC, Hancock SJ, Schadtle. Immediate release dosage forms containing solid drug disbursion, U.S. Patent, pp 424 465; 2002.
- Mishra B, Shukla D, Chakraborty S, Singh S, An overview of formulation of mouth dissolving tablets, Scientia Pharmaceutica, pp 77, 309-326. 2009
- Menat AK, Patel MS, Patel MR, Patel NM, Fast dissolving tablets a novel approach to drug delivery. Asian J. Pharm. Sci. Res., vol. 2, no. 8, pp 13-21. 2012
- Garg A, Gupta MM, A review of mouth dissolving tablets. J. Drug Delivery Therapeutics, vol. 3, no.2, pp 207-214. 2013
- Jagani H, Patel R, Upadhyay P, Bhangale J, Kosalge S, Fast dissolving tablet on present and future prospectus. J. Advances In Pharmacy And Healthcare, vol. 2, no. 1, pp 57-69. Res. 2011
- Hirani JJ, Rathod DA, Vadalia KR, A review in orally disintegrating tablets. Tropical J. Pharm., vol. 8, no. 2, pp 161-172. Res. 2009
- Patel P, Dhanani C, Kadeval A, Patel M, Patel N‚ Patel R, A modern approach on fast dissolving tablets. Int. J. Modern Pharm., vol. 1, no.2, pp 1-17. Res. 2012
- Leon Lachmann, Herbert A, Liberman, Joseph L.Kaing, The theory and practice of Industrial Pharmacy: pp 293-303.
- Ansel‘s Pharmaceutical dosage forms and drug delivery systems, eighth edition, pp 227- 260.
- Snehal B. Kulkarni, M. M. Bari, S. D. Barhate, Ashutosh Tripath. Formulation and Evaluation of Immediate Release Tablet of Efavirenz by Micellar Solubilization Technique. Asian J. Pharm. Res. 2019; 9(1): 12-18.
- Rajeshree Panigrahi, K.A. Chowdary, Gitanjali Mishra, Manas Bhowmik, Saiprasanna Behera. Formulation of fast dissolving tablets of Lisinopril using combination of synthetic superdisintegrants. Asian J. Pharm. Tech. 2(3): July-Sept. 2012; Page 94-98.
- S. Kumara Swamy, G. Arun, Bethi Srinivas, Agaiah Goud B. Effect of Various Super Disintegrants on the Drug Release Profile of Orally Disintegrating Tablets. Asian J. Pharm. Tech. 2016; 6(2): 99-105.
- Renuka S. Deshmukh, M. M. Bari, S. D. Barhate. Formulation and Evaluation of Orodispersible Tablet of Naratriptan HCl. Asian J. Pharm. Tech. 2018; 8 (3):139-144 .
- Design and Evaluation of the Fast Dissolving Tablets of Aceclofenac by Sublimation Technique. Sumanta Malakar, Ashok Kumar P., Suresh V. Kulkarni, Someshwara Rao B., Amit S. Yadav. Research J. Pharma. Dosage Forms and Tech. 2010; 2(3):233-236 .
- V. Saikishore, G. Srikanth, Ch. Pooja, Y. Mrudula, R. Pavani, Ch. Jyosthna , C. Mayuren. Design and Development of Fast Dissolving Tablets of Glibenclamide. Research J. Pharma. Dosage Forms and Tech. 2011; 3(5): 225-229.
- A. Pavan Kumar, V. Sai Kishore, T. E. Gopala Krishna Murthy, K. Madhu Babu,. Formulation of Valsartan Fast Dissolving Tablets Using Novel Co Processed Superdisintegrants. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1): 52-55.
- Sharad A. More, Shrinivas K. Mohite. Formulation Development and Evaluation of Orodispersible Tablet of Omeprazole by Using Co-Processed Superdisintegrant. Research J. Pharma. Dosage Forms and Tech. 2012; 4(4): 216-220.
- V. Kalyani, V. Sai Kishore, U. Kartheek, S. Aruna, A. Navya Krishna. Design and Development of Olanzapine Immediate Release Tablets by using Natural Super Disintegrant. Res. J. Pharm. Dosage Form. and Tech. 6(2):April- June 2014; Page 85-90.
- V. Kalyani, V. Sai Kishore, U. Kartheek, S. Aruna, A. Navya Krishna. Design and Development of Olanzapine Immediate Release Tablets by using Natural Super Disintegrant. Res. J. Pharm. Dosage Form. and Tech. 6(2):April- June 2014; Page 85-90.
- Omprasad Nayakal, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge. Formulation and Evaluation of Fast Dissolving Tablets containing Clopidogrel bisulfate using holy basil seeds as a natural superdisintegrant. Res. J. Pharm. Dosage Form. and Tech. 2018; 10(4): 209-214.
- Ranabir Chanda, H. Padmalata 1 Venkatesh, Janmajoy Banerjee Formulation and Evaluation of Oral Disintegrating Tablets of Ondansetron Hydrochloride. Res. J. Pharma. Dosage Forms and Tech.2019; 11(1):53-63.
- Y. Krishna Reddy1*, Gopagoni lavanya. Formulation and In Vitro Evaluation of orally Disintegrating Tablets of Amlodipine Besylate. Res. J. Pharma. Dosage Forms and Tech.2019; 11(4):264-268.
- SC Jagdale, AR Chabukswar, BS Kuchekar, AN Padalkar, AU Kale. Comparative Evaluation of Superdisintegrants with Formulation Development of Orodispersible Tablets of Mosapride Citrate Dihydrate. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 91-96.
- Venkatalakshmi R, Sasikala C, SP Silambarasan. Formulation and Evaluation of Loperamide Hydrochloride Mouth Dissolving Tablet by Using Super Disintegrants. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 530-534.
- Risk assessment of different edible oils subjected to heat at different time intervals and analyzed by titrimetric and instrumental methods and biological estimation on Wistar albino rats
Authors
1 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
Source
Asian Journal of Research in Chemistry, Vol 15, No 1 (2022), Pagination: 35 - 41Abstract
Oils and fats in the diet serve three functions in the human body: as an energy source, a structural component, and as important biological regulators. Lipid peroxidation may be accelerated by repeatedly heating soy oil. Unsaturated fatty acids that have been oxidised may play a role in the aetiology of a variety of diseases. The purpose of this study was to see if repeatedly heating edible oil had any negative consequences on illness development. In this investigation, four different edible oils were heated to their regular boiling point and then heated for another 3 hours at a 1hour interval. The heated samples were subjected to qualitative examination. After analysing the results, it was discovered that saponification values declined as continuous heating, i.e. 3 hours, was applied to all different oils, resulting in low saponification values when compared to 2 hours, 1 hour, and normal boiling point. Lower the saponification value, the more free fatty acids and triglycerides are produced, which may contribute to cardio vascular illness. The acid values grew as the heating progressed, according to the findings. A high acid number suggests that there is a lot of acid in the system. The values of iodine fell as the heating progressed, according to the results. The presence of saturated fatty acids is indicated by a low iodine value. Saturated fatty acids were detrimental to one's health. As the heating progressed, the peroxide levels grew. Deterioration is indicated by an increase in peroxide value. When compared to other oils, palm oil showed a high saponification value, acid value, peroxide value, and low iodine value. Total cholesterol, tri-glycerides, and glucose levels were higher in 3 hours heated oils than in 2 hours, 1 hour, and at normal boiling point in biological tests .Keywords
Edible oil, Heating, Fatty acids, Deterioration, Peroxide values.References
- Bello, “Physico-chemical properties of some commercial groundnut oil products sold in sokoto metropolis, northwest Nigeria,” 2011.
- V. W. K. Fupi and P. C. Mørk, “Mafura nut oil and meal: processing and purification,” Journal of the American Oil Chemists’ Society, vol. 59, no. 2, pp. 94–98, 1982.
- H. Khan, M. Fida, I. U. Mohammadzai, and M. Khan, “Estimation of residual nickel and some heavy metals in vanaspati ghee,” Journal of the Chinese Chemical Society, vol. 54, no. 3, pp. 737– 741, 2007.
- M. Anthea, J. Hopkins, C. W. McLaughlin et al., Human Biology and Health, Prentice Hall, Englewood Cliffs, NJ, USA, 1993.
- D. Mendil, O. D. Uluozl ¨ u, M. Tuzen, and M. Soylak, “Investiga¨ tion of the levels of some element in edible oil samples produced in Turkey by atomic absorption spectrometry,” Journal of Hazardous Materials, vol. 165, pp. 724–728, 2009.
- M. Rose, M. Knaggs, L. Owen, and M. Baxter, “A review of analytical methods for lead, cadmium, mercury, arsenic and tin determination used in proficiency testing,” Journal of Analytical Atomic Spectrometry, vol. 16, no. 9, pp. 1101–1106, 2001.
- E. Johannesen, “Palm fruit oil-much more than ordinary oil,” Journal of Science in Africa Magazine, 2005.
- R. Manorama and C. Rukmini, “Nutritional evaluation of crude palm oil,” The Oil Technologists’ Association of India, vol. 22, pp.83–87, 1991
- R. Shaik, Analytical tool for rapid analysis of edible oil [M.S. thesis], Aalborg University Esbjerg, 2008.
- ISI Hand book of food Analysis (part III) 1984 page 67/ IUPAC2.201 (1979) I.S, 548 (Part-1)-1964 method of sampling and test for oils and fats/ISO 6601 1996 Determination of acid value and acidity.
- A.O.A.C, Official Method 920.160-Saponfication Number of Oils and Fats/IUPAC 2.202 I.S.I Hand Book of Food Analysis (Part XIII 1984), A.O.A.C, 17th edition, 2000.
- A.O.A.C, Official Method 920.159-Iodine Absorption Number of Oils and Fats/I.S.I Hand Book of Food Analysis Part-III-1984, A.O.A.C, 17th edition, 2000.
- A.O.A.C, Official Method 965.33 Peroxide value in oils and fats/Pearson’s composition and analysis of food, 17th edition, pp.641, 2000.
- F. Camin, R. Larcher, M. Perini et al., “Characterisation of authentic Italian extra-virgin olive oils by stable isotope ratios of C, O and H and mineral composition,” Food Chemistry, vol. 118, no. 4, pp. 901–909, 2010.
- Z. Mester and R. Sturgeon, Sample Preparation for Trace Element Analysis: Comprehensive Analytical Chemistry, Elsevier Science, Amsterdam, The Netherlands, 2003.
- E. Weiner, Environmental Chemistry: A Practical Guide for Environmental Professionals, Taylor and Francis Group, Boca Raton, Fla, USA, 2nd edition, 2007.
- USEPA Method 200.5, “Determination of trace elements in drinking water by axially viewed inductively coupled plasma— atomic emission spectrometry,” Tech. Rep. EPA/600/R-06/115, 2003.
- O. Ogbonna, L. Jimoh, F. Awagu, and I. Bamishaiye, “Determination of some trace elements in water samples within Kano, Metropolis,” Pelagia Research Library, vol. 2, no. 2, pp. 62– 68, 2011.
- O. C. Othman and F. N. Ngassapa, “Physico-chemical characteristics of some imported edible vegetable oils and fat marketed in Dar es salaam, Tanzania,” Tanzania Journals of Natural and Applied Science, vol. 1, no. 2, 2010.
- Manjula B, Shivalinge Gowda KP, Syed Mansoor Ahamed, Nagarjan T, Gaurav G. Role of Omega Fatty Acids in Human Body. Asian J. Research Chem. 2(2): April.-June, 2009 page 9399.
- Himanshu Joshi, Arun B Joshi, Hemlata Sati, Gururaja MP, Prajwal R Shetty, EVS Subrahmanyam, D Satyanaryana. Fatty Acids from Memecylon umbellatum (Burm.). Asian J. Research Chem. 2(2): April.-June, 2009 page 178-180.
- Neelam Vaidya, Rakesh Choure. Electrochemical Analysis of Fatty Acids Obtained from the Natural Resource Seed of Perilla frutescens. Asian J. Research Chem. 4(5): May, 2011; Page 705707.
- Gargee Yadav. Oil Content and Fatty Acid Variation in some Indian Accessions of Safflower (Carthamus tinctorious L.) Seed and Oil. Asian J. Research Chem. 5(10): October, 2012; Page 1289-1292.
- Gargee Yadav, H.C. Srivastava. Fatty Acid Composition and Oil Content of Some Safflower (Carthamus tinctorius L.) Cultivars of Indian Origin. Asian J. Research Chem. 6(7): July 2013; Page 634-636.
- Govindu Vani, Pranabesh Sikdar, J. Swathi Kiran, C. Pushpalatha, T. Sireesha, P. Reddy Rani, M. Vishnu Vardhan, M. Niranjan Babu. Evaluation of Physicochemical properties of some Edible
- oils available in Tirupathi. Res. J. Pharmacognosy and Phytochem.2019; 11(3):179-185.
- Savitha P., Saravana Kumar S.2. Effect of Omega-3 Fatty acids on Memory – Review. Research J. Pharm. and Tech. 7(6): June, 2014;Page 715-718.
- DhiaF.Alfekaiki. Characteristics of Fat Milk Iraqi Buffalo (Bubalusbubalis). Research J. Pharm. and Tech 2018; 11(10):4349-4356.
- R. Kamalambigeswari, S. Sharmila, E. Kowsalya, S. Selva Janani, V. Deva, L. Jeyanthi Rebecca. Extraction of Omega-3 Fatty Acid -methyl stearate from Soil Fungi (Fusarium sp.). Research J.
- Pharm. and Tech 2019; 12(9):4295-4298.
- Rania Matar, Mayssam Salami, Zaid Al Assaf. Factors affecting the Formation of Elaidic acid in Syrian Edible Oils during Frying with Home Conditions. Research J. Pharm. and Tech. 2019;
- (11): 5451-5455.
- Synthesis, characterization, anti-inflammatory and anti-oxidant activities of novel 2, 4-di substituted 1, 5- benzodiazepine derivatives
Authors
1 Department of Pharmaceutical Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
2 Department of Chemistry, Vijaya Teja Degree College, Addanki-523201, Andhra Pradesh ., IN
3 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh ., IN
4 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
5 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
Source
Asian Journal of Research in Chemistry, Vol 15, No 2 (2022), Pagination: 109 - 114Abstract
The study's goal is to synthesis novel benzodiazepine analogues, some of which are chalcones. The elemental analysis, infrared, and 1H nuclear magnetic resonance examinations examined the structures of the newly produced substances. To test for anti-inflammatory and anti-oxidant properties, all substances bearing a descriptor were evaluated. Here, 1,5-(disubstituted phenyl)-2,4-pentadien-1-one derivatives are created from scratch using a new process. By condensing cinnamaldehyde with different aromatic ketones in the presence of 10% NaOH as a base, 1,5-(disubstituted phenyl)-2,4-pentadien-1-one was produced. 2-(substituted phenyl)-3- styryl-2,3-dihydro-1H-benzodiazepine derivatives were synthesised from 1,5-(disubstituted phenyl)-2,4- pentadien-1-one on cyclization with o-phenylene diamine in the presence of NaOH as base. Carrageenan and formalin-induced rat paw edoema technique was used to evaluate the antioxidant and anti-inflammatory activities of the final synthesised benzodiazepine derivatives. Compared to the usual ascorbic acid and diclofenac sodium, the compounds displayed significant anti-inflammatory effect. This means that nitro, chloro, fluoro, and bromo included electron withdrawing groups, which caused an increase in anti-inflammatory action. Most of the produced drugs had strong anti-inflammatory efficacy .Keywords
Chalcones, 1,5-benzodiazepines, Anti-inflammatory activity, Anti-oxidant activity.References
- Ilango SS, Remya PU, Ponnuswamy S. Synthesis and antimicrobial activity of novel 1,5-benzodiazepines. Indian J Chem 2013;52B(01):136-40.
- Kudo Y. Hypnotic effects of a benzodiazepine derivative: A clinical observation. Int Pharmacopsychiatry 1982;17(1):49-64.
- De Sarro G, Gitto R, Rizzo M, Zappia M, De Sarro A. 1,4Benzodiazepine derivatives as anticonvulsant agents in DBA/2 mice. Gen Pharmacol 1996;27(6):935-41.
- Najafi N, Pirali M, Dowlatabadi R, Bagheri M, Rastkari N, Abdollahi M. Synthesis and analgesic and anti-inflammatory properties of new benzodiazepine derivatives. Pharm Chem J 2005;39(12):641-3.
- Fruscella P, Sottocorno M, Di Braccio M, Diomede L, Piccardi N, Cagnotto A, et al. 1,5-Benzodiazepine tricyclic derivatives exerting anti-inflammatory effects in mice by inhibiting interleukin-6 and prostaglandinE(2)production. Pharmacol Res 2001;43(3):445-52.
- Tardibono LP, Miller MJ. Synthesis and anticancer activity of new hydroxamic acid containing 1,4-benzodiazepines. Org Lett 2009; 11(7):1575-8.
- Lingjaerde O. Effect of the benzodiazepine derivative estazolam in patients with auditory hallucinations. A multicentre double-blind, cross-over study. Acta Psychiatr Scand 1982;65(5):339-54.
- Nowakowska Z. A review of anti-infective and anti-inflammatory chalcones. Eur J Med Chem 2007;42(2):125-37.
- Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, et al. Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Bioorg Med Chem Lett 2010;20(3): 942-4.
- Syam S, Abdelwahab SI, Al-Mamary MA, Mohan S. Synthesis of chalcones with anticancer activities. Molecules 2012;17(6):6179-95.
- Hsieh HK, Tsao LT, Wang JP, Lin CN. Synthesis and antiinflammatory effect of chalcones. J Pharm Pharmacol 2000; 52(2): 163-71.
- Bandgar BP, Gawande SS, Bodade RG, Totre JV, Khobragade CN. Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents. Bioorg Med Chem 2010;18(3):1364-70.
- Xuan F, Juhua F, Zhenhua D, Lili L, Xiaohua L, Xiaoming F. Enantioselective synthesis of 2-substituted-1,5-benzodiazepines through domino reaction of o-phenylenediamine and chalcone derivatives. Eur JOC 2010;27:5233.
- Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paws of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol Med 1962; 111:544-7.
- C. A. Winter, E. A. Risley, and G. W. Nuss. Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Experimental Biology and Medicine. 1962; 111(3): 544–547.
- P. Crunkhorn and S. C. R. Meacock. Mediators of the inflammation induced in the rat paw by carrageenan. British Journal of Pharmacology. 1971; 42(3): 392–402.
- M. Di Rosa and L. Sorrentino. The mechanism of the inflammatory effect of carrageenan. European Journal of Pharmacology. 1968; 4(3): 340–342.
- Swarajyam Y. A Study to Assess the Knowledge and Practices of Mothers Regarding Worm Infestation among School age Children (612 Years) in Order to Develop Health Education Pamphlet in a Selected Rural Community, Bangalore. Asian J. Nur. Edu. & Research 1(1): Jan.-March 2011; Page 28-30.
- P. Balakrishnan. A Comparative study to assess the knowledge and attitude of adolescents (16-18 years) regarding alcoholism and its hazards between selected rural and urban Pre-University College at Bangalore. Asian J. Nur. Edu. & Research 1(1): Jan.-March 2011; Page 31-36.
- Ganesh. A study to assess the effectiveness of structured-teaching programme on knowledge regarding rheumatic fever among school children between the age group of 14 –15 years in a selected school, Chidambaram. Asian J. Nur. Edu. & Research 2(1): Jan.-March 2012; Page 12-14
- Sherin A. Hameed, Joyamma Varkey, P. Jayasekhar. Schiff bases and Bicyclic derivatives comprising 1, 3, 4-thiadiazole moiety- A Review on their Pharmacological activities. Asian J. Pharm. Res. 2019; 9(4):299-306.
- Prajakta P Shinde, Shahu D Khule, Sneha Sonawane, Suvarna Shelke. Analgesic activity and anti-inflammatory activity of methanolic extract of plant Sida cordata in carrageenan-induced paw edema in rats. Asian Journal of Pharmaceutical Research. 2021; 11(3):143-6.
- Kiran Madhawai, Dinesh Rishipathak, Santosh Chhajed, Sanjay Kshirsagar. Predicting the Anti-Inflammatory Activity of Novel 5Phenylsulfamoyl-2-(2-Nitroxy) (Acetoxy) Benzoic acid derivatives using 2D and 3D-QSAR (kNN-MFA) Analysis. Asian J. Res. Pharm.Sci. 2017; 7(4): 227-234.
- Debarshi Kar Mahapatra, Ruchi S. Shivhare, Sayan Dutta Gupta. Anxiolytic activity of some 2, 3-dihydrobenzo[b] [1, 4] oxazepine derivatives synthesized from Murrayanine-Chalcone. Asian J. Res.
- Pharm. Sci. 2018; 8(1):25-29.
- Dhananjay Babanrao Deshmukh, Mahesh Ramrao Sherkar. Evaluation of In Vivo Analgesic and Anti-Inflammatory Activity of Ethanolic Extract of Medicinal Plant-Lagenaria siceraria. Asian J. Pharm. Tech.
- ; 9(2):75-78.
- Sujata S. Sawant, Sangram S. Patil, Hemant S. Kandle, Manohar D. Kengar, Ganesh B. Vambhurkar, Mangesh A. Bhutkar. Development and Characterization of Lornoxicam loaded microsponge gel for
- Rheumatoid arthritis. Asian J. Pharm. Tech. 2019; 9(3):173-178.
- Vani Mamillapalli, Ratna Harika Chapala, Tejaswi Komal Sai Sareddu, Latha Sri Kondaveeti, Santhi Pattipati, Padmalatha Khantamneni.Evaluation of Phytochemical and in Vitro Anti-Inflammatory activity
- of Leaf and Fruit Extracts of Casuarina equisetifolia. Asian J. Pharm.Tech. 2020; 10(3):143-148.